Abstract:Mutations of TBX5 cause Holt-Oram syndrome (HOS) in human, a disease characterized by upper limb and heart defects. Mouse embryos of
Osr1
knockout caused similar heart defects, while the upper limb defects have never been reported. By genetically marking
Osr1
expressing cells in mice, using
Osr1:CreERT2
, we showed that
Osr1
expression cells contribute to the atrial septum progenitors between E8.0 and E11.0, and to … Show more
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