Abstract:Invadopodia are ventral membrane protrusions that are formed by invasive cancer cells cultured on physiological substrates. They are actin-based structures and promote the degradation of the extracellular matrix by focally localizing matrix metalloproteinases. Accumulating evidence suggests that invadopodia play an important role in local invasion and distant metastasis of malignant tumors. Actinin is an actin-binding protein that forms dimers and crosslinks actin filaments. There are four isoforms of actinin … Show more
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