“…Understanding the dynamics of cardiomyocyte ploidy is of paramount importance for deciphering the cellular mechanisms propelling cardiac development, 1 regeneration, 2 and disease. 3 Cardiomyocytes possess diverse ploidy levels that can vary significantly among the cell population. Both polyploidization and ploidy reduction are well documented in liver hepatocytes in response to injury and repair, but these processes are poorly understood in the context of the heart.…”