Abstract:Purpose: The FDA cleared CellSearch assay for enumeration of Circulating Tumor Cells (CTC) detects CTC by fluorescence microscopy after immunomagnetic enrichment targeting Epithelial Cell Adhesion Molecule (EpCAM). The system generated thumbnail images of DNA+, Cytokeratin+ (CK+) events and presents these to a reviewer for scoring events as CTC. An event is a CTC when it is negative for CD45, positive for DNA and CK and is larger than a 4 × 4 μm2 with a cell-like morphology. The presence of CTC defined in such… Show more
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