Abstract 3405: MicroRNA expression characterizes oligometastasis(es)

Xing, Rosie Hongmei; Lussier, Yves A.; Salama, Joseph K.; Khodarev, Nikolai N.; Huang, Yong; Zhang, Qingbei; Khan, Sajid; Yang, Xinan; Hasselle, Michael D.; Darga, Thomas E.; Malik, Renuka; Fan, Huiying; Perakis, Samantha; Filippo, Matthew; Corbin, Kimberly S.; Lee, Younghee; Posner, Mitchell C.; Chmura, Steven J.; Hellman, Samuel; Weichselbaum, Ralph R.

doi:10.1158/1538-7445.am2012-3405

Cited by 7 publications

(1 citation statement)

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“…A one-tailed t-test was used to identify differentially expressed miRNAs with p value < 0.05(Xing et al, 2012). The hierarchical clustering of the differential expression mRNAs was made and showed different expression patterns between the N816S and Ning5m (Figure 5A).…”

Section: Resultsmentioning

confidence: 99%

MiRNAs profiling and degradome sequencing between the CMS-line N816S and its maintainer line Ning5m during anther development in pepper (Capsicum annuumL.)

Zhang

Huang

Tan

et al. 2020

Preprint

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Section: Resultsmentioning

confidence: 99%

MiRNAs profiling and degradome sequencing between the CMS-line N816S and its maintainer line Ning5m during anther development in pepper (Capsicum annuumL.)

Zhang

Huang

Tan

et al. 2020

Preprint

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Malignant Peripheral Nerve Sheath Tumor in Cowden Syndrome

Taylor¹,

Delon

Allinson

et al. 2015

J Neuropathol Exp Neurol

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Malignant peripheral nerve sheath tumor is a rare malignancy, accounting for 3% to 10% of all soft-tissue sarcomas. We describe a previously healthy 48-year-old man who was diagnosed as having a high-grade malignant neoplasm involving the facial nerve in the right petrous canal after a 4-year history of deafness. The tumor was resected; histologic appearance and immunophenotype, including patchy but strong positivity for S100 protein, indicated a diagnosis of malignant peripheral nerve sheath tumor. A PTEN mutation, c.1003C>T p.(Arg335Ter), was subsequently identified as the cause of Cowden syndrome in another family member (a nephew) with dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease), and genetic testing in the proband's daughter indicated that he was an obligate carrier of the mutation. Sequencing of the tumor showed homozygosity for c.1003C>T, confirming the presence of a germline mutation and implying loss of the second allele. With the exception of Lhermitte-Duclos disease, tumors of the nervous system are not a prominent feature of Cowden syndrome, and this is the first report of malignant peripheral nerve sheath tumor in Cowden syndrome. Sequencing results in the tumor lend evidence to PTEN gene inactivation being implicated in tumorigenesis in this case, suggesting causality rather than chance association.

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Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

Bhatia

Larsson

Calizo

et al. 2022

Preprint

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Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1-MPNST), but can occur sporadically. Through a multi-institution collaboration, we have developed 13 NF1-associated MPNST patient-derived xenografts (PDX). Genomic analysis of the PDX-tumor pairs identified somatic mutations in NF1 (61%), SUZ12 (61%), EED (15%), and TP53 (15%), and chromosome 8 (Chr8) gain (77%), consistent with published data. Pre-clinical models that capture this molecular heterogeneity are needed to identify and prioritize effective drug candidates for clinical translation. Here, we describe the successful development of a medium-throughput ex vivo 3D microtissue model with several advantages over 2D cell line growth, which can be utilized to predict drug response in vivo. Herein, we present proof-of-principle of this PDX-to-microtissue system, using four genomically representative MPNST and three drugs. This work highlights the development of a novel ex vivo to in vivo preclinical platform in MPNST that successfully captures the genomic diversity observed in patients and represents a resource to identify future therapeutic strategies.

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Abstract 3405: MicroRNA expression characterizes oligometastasis(es)

Cited by 7 publications

References 0 publications

MiRNAs profiling and degradome sequencing between the CMS-line N816S and its maintainer line Ning5m during anther development in pepper (Capsicum annuumL.)

MiRNAs profiling and degradome sequencing between the CMS-line N816S and its maintainer line Ning5m during anther development in pepper (Capsicum annuumL.)

Malignant Peripheral Nerve Sheath Tumor in Cowden Syndrome

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

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