Abstract:Introduction:
Re-establishing vasculature after a myocardial infarction (MI) may spare cardiomyocytes from death due to lack of sufficient oxygen. WISP-1 -a secreted matricellular protein that regulates angiogenesis in certain cancers- promotes cell survival in isolated cardiomyocytes
in vitro
. However, the potential role WISP-1 plays post-MI, has not been evaluated. Histone deacetylase inhibition (HDACi) attenuate adverse effects of an MI in small animal models but it is u… Show more
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