Abstract:Pancreatic ductal adenocarcinoma (PDAC) is a disease with poor survival. Somatic KRAS mutations are present in almost 95% of PDAC patients and are known to a play pivotal role in PDAC genesis and progression. The G12D substitution is the predominant form detected in PDAC. By constitutively activating diverse downstream signaling pathways (like ERK/MEK) KRAS mutations are known to drive autocrine growth transformation in cancer cells. However, the lack of therapeutics for direct targeting of mutant KRAS necessi… Show more
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