Abstract #313: Pattern of Dyslipidemia Among Nigerians With Type 2 Diabetes Mellitus

Okafor, Charles O.; Oke, David Mautin; Fasanmade, O.A

doi:10.1016/s1530-891x(20)44060-1

Cited by 4 publications

(5 citation statements)

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“…10,11 The pattern of dyslipidaemia in our study revealed LDL 51.9%, TG 37.5%, TC 36.5% and HDL 27.9% which compares with other studies that demonstrates the typical diabetic dyslipidaemia. 12,13 Although obesity and type 2 diabetes commonly co-exist. 14 We had more patients who were overweight 33.7% than obese 32.7% which is comparable with other findings, increased physical activity and dietary modifications were discussed and re-emphasised to our patients early at diagnosis of T2M and this could contribute to why our patients were overweight than obese which still buttress the need for more lifestyle modification.…”

Section: Discussionmentioning

confidence: 99%

Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

2021

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Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Diabetic patients have an increased risk of developing dyslipidemia with various lipid abnormalities which makes them prone to develop cardiovascular disease. The aim of the study is to determine the patterns of lipid profile in patients with Type 2 diabetes mellitus.Methods: Lipid profile data for a total of 104 known type 2 DM patients from the medical outpatient clinic were collected. The profile of the study sample was analysed for dyslipidemia using the ATP III classification. Data obtained were analysed using Analyse-it v3.0 statistical software for Microsoft Excel.Results: This study showed that there were more females 53.8% than males 46.2% with type 2 diabetes mellitus with the mean age of 52.5±11.9 years. The pattern of dyslipidaemia revealed elevated LDL 51.9%, TG 37.5%, TC 36.5% and low HDL 27.9%. We had more patients who were overweight 33.7% than obese 32.7%.Conclusions: It was observed from the study that a significant number of diabetic patients have dyslipidaemia and most common lipid abnormalities are elevated LDL, triglyceride and low HDL.

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Section: Discussionmentioning

confidence: 99%

Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

2021

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“…[49] Similarly, in a meta-analysis done among Ethiopians living with T2D, the prevalence of low HDL-C was reported as 44.36%, which is similar to the findings of this present meta-analysis. [50] Insulin resistance enhances the increased production of TRLs which exchange triglyceride Isezuo et al [19] 2003 Cross-sectional 40 25% NW Isezuo and Ezunu [20] 2005 Cross-sectional 254 72.4% NW Idogun et al [21] 2007 Cross-sectional 52 30% SS Okafor et al [22] 2008 Cross-sectional 192 89% SW Unadike et al [23] 2008 Cross-sectional 32 68.7% SS Ogbera et al [24] 2009 Cross-sectional 600 89% SW Kayode et al [25] 2010 Cross-sectional 113 50.4% SW Edo and Adediran [26] 2011 Cross-sectional 52 32.7% SS Jisieike-Onuigbo et al [27] 2011 Cross-sectional 108 90.7% SE Okafor et al [22] 2012 Cross-sectional 233 97.1 SE Oyelade et al [28] 2013 Cross-sectional 219 58.5% SW Edo et al [29] 2014 Retrospective 63 30.2% SS Ogedengbe and Ezeani [30] 2014 Cross-sectional 106 50.8% SE Edo and Edo [31] 2016 Retrospective 130 29.2% SS Enikuomehin et al [32] 2016 Cross-sectional 300 50.4% SW Fasanmade et al [33] 2016 Cross-sectional 218 80.7% SW Young and Onyenekwe [34] 2016 Cross-sectional 51 82.4% SE Omotoye and Fadupin [35] 2017 Cross-sectional 50 70% SW Engwa et al [36] 2018 Cross-sectional 72 40.8% SE Bello-Ovosi et al [37] 2019 Cross-sectional 322 69.3% NW Jaja and Yarhere [38] 2019 Cross-sectional 22 86.4% SS Amadi et al [39] 2020 Retrospective 346 46.8% SS NW: North-west, SS: South-south, SW: South-west, SE: South-east with cholesterol on HDL-C, making the HDL-C more susceptible to increased clearance from the bloodstream. [51] This invariably leads to low HDL-C.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of dyslipidemia among Nigerians with T2D is very high. The most commone abnormalities are Isezuo et al [19] 40 0 10.5 28.1 12.3 Idogun et al [21] 52 92.3 30.8 100 92.3 Okafor et al [22] 192 58.9 25 88 55.2 Ogbera et al [24] 600 74 53 13 42 Kayode et al [25] 113 0 10.5 28.1 12.3 Edo and Adediran [26] 52 9.6 19.2 32.7 26.9 Jisieike-Onuigbo et al [27] 108 44.4 56.5 62 53.7 Oyelade et al [28] 219 23.7 16 44.3 12.3 Edo et al [29] 63 30.2 7.9 25.4 17.5 Ogedengbe and Ezeani [30] 106 41.1 27 50.8 34.7 Edo and Edo [31] 130 26.9 9.2 29.2 13.1 Enikuomehin et al [32] 187 38.3 24.7 28.3 28.3 Omotoye and Fadupin [35] 50 34 86.4 72 36 Engwa et al [36] 72 27.7 40.8 NA 39.4 Jaja and Yarhere [38] 22 34 86.4 36.4 22.7 Amadi et al [39] 346 NA 87. hypertriglyceridemia and low HDL-C. Clinicians need to be aware of this so as to pay a closer attention to the lipid profiles of their patients with T2D.…”

Section: Discussionmentioning

confidence: 99%

Lipid profiles of Nigerians living with type 2 diabetes mellitus: A systematic review and meta-analysis

Azeez¹,

Adio

Bamidele

2021

Journal of Diabetes and Endocrine Practice

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Introduction: Dyslipidemia is often associated with type 2 diabetes (T2D), with both having an additive effect on cardiovascular risk. The objective of the meta-analysis was to determine the prevalence of dyslipidemia in individuals living with T2D mellitus in Nigerian and to examine the pattern of their dyslipidemia. Methods: The study followed the preferred reporting items for systematic reviews and meta-analyses guidelines. Medical databases such as PubMed, Google Scholar, African Journals Online, and SCOPUS as well as the gray literature were systematically searched. MetaXL was used for statistical analysis adopting the random effect model. Heterogeneity was determined using the I2 statistic, while publication bias was assessed with the funnel plot. Results: Twenty-two studies met the eligibility criteria for the meta-analysis. The total sample size was 3575. The prevalence of dyslipidemia among Nigerians living with diabetes ranges from 25% to 97.1%. The pooled prevalence of dyslipidemia among Nigerians living with T2D was 63% (95% confidence interval [CI]: 52%–72%). I2 statistic was 97%. The funnel plot implied minimal publication bias. The pooled prevalence of elevated low-density lipoprotein cholesterol was 33% (95% CI: 18%–49%). The pooled prevalence of elevated hypertriglyceridemia was 88% (95% CI: 84%–91%). The pooled prevalence of low high-density lipoprotein cholesterol (HDL-C) was 47% (95% CI: 32%–62%). The pooled prevalence of elevated hypercholesterolemia was 33% (95% CI: 23%–43%). Conclusions: The prevalence of dyslipidemia among Nigerians with T2D mellitus is very high. The most common abnormalities are hypertriglyceridemia and low HDL-C.

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“…5 Dyslipidemia is a well recognized and modifiable risk factor for cardiovascular diseases which is currently a leading cause of morbidity and mortality worldwide in both developed and underdeveloped regions. 6,7 In addition, atherosclerotic cardiovascular disease has been linked to cigarette smoking. Multiple processes, including vascular damage, thrombosis, vascular dysfunction, and lipid peroxidation, account for the impact of smoking on atherosclerosis development.…”

Section: Introductionmentioning

confidence: 99%

Lipid Profile Levels in Smokers

Javed¹,

Hafiz²,

Tahir³

et al. 2022

PJMHS

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Objective: The objective of this study was to record mean lipid profiles in smokers Methodology: All 200 (Two hundred) smokers were enrolled from Cardiology Department, Punjab Institute of cardiology Lahore during 2015 to 2016, the demographic profile of the patients’ was taken. Their ECG was done to ensure that they do not have any cardiac disease. After 12 hours over night fasting, blood samples were withdrawn from a cubital vein into blood tubes. The blood samples were sent to hospital laboratory for the analysis of lipid profile. Serum triglyceride (TG) level by GPO – PAP enzymatic colorimetric method, Serum total cholesterol (TC) level by CHOD – PAP enzymatic colorimetric method, Serum HDL-c level by precipitation method, Serum LDL-c level by using Friedewald’s formula, LDL-c = TC ˗ (HDL + TG/5), Serum VLDL-c level by using Friedewald’s formula VLDL-c = TG/5. Results: Of 200 cases 45%(n=90) were between 18-40 years of age while 55%(n=110) were between 41-60 years of age, mean+sd was calculated as 41.98+11.02 years, 89.5%(n=179) were male and 10.5%(n=21) were females, mean lipid profiles in smokers was calculated as 188.38+16 55 for total cholesterol, 157.33+15.93 triglycerides, 42.47+4.88 HDL, 114.44+13.43 LDL and 31.47+3.19 for VLDL. Conclusion: the smokers are at higher risk of developing dyslipidemia. Our results are encouraging for smokers to quit their habits to live a healthy life. Keywords: Smokers, lipid profile, mean

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Abstract #313: Pattern of Dyslipidemia Among Nigerians With Type 2 Diabetes Mellitus

Cited by 4 publications

References 0 publications

Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

Lipid profiles of Nigerians living with type 2 diabetes mellitus: A systematic review and meta-analysis

Lipid Profile Levels in Smokers

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