Abstract:Platelets have a well documented role in atherosclerotic lesion formation. They play a role from the initiation of the lesion to final occlusion of an atherosclerotic vessel. While it is known that regulating aggregation is important to control the thrombus that leads to occlusion, the platelet’s role in promoting lesion formation is less defined. Molecules stored in the platelet a-granules such as p-selectin and cytokines, which promote the inflammatory side of platelet function, have been shown to affect les… Show more
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