Abstract 3054: Proteomics and microRNA characterization of mammary tumor and adipose tissue-derived EVs and their combined impact on cancer cell metabolism
Abstract:Background: Obesity increases the risk of triple negative breast cancer (TNBC) and its progression to metastasis, the primary cause of death in women with TNBC. In obesity, dysregulated adipose tissue secretes growth factors and hormones, promoting chronic inflammation. Adipose tissue also secretes extracellular vesicles (EVs), cell-derived nanoparticles (50 - 5000 nm diameter) containing proteins and nucleic acids that interact with and modify local and distant cellular targets. Research from our team and oth… Show more
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