Abstract 3008: PSMA glycosylation and aggressive prostate cancer progression

Recent Advances in Analytical Approaches for Glycan and Glycopeptide Quantitation

“…As a result of these advances, targeted glycomic research continuously expands the implication of glycosylation in physiological processes such as cell signaling (11)(12)(13)(14), host-pathogen interaction (15)(16)(17)(18), and immune response (11,(19)(20)(21), with significant revelations provided in connection to human disease. Recent evaluations demonstrating the importance of glycosylation in neurodegenerative diseases (22,23), diabetes (24,25), and cancer (26)(27)(28) promote further interest in glycomic investigation to reveal potential biomarkers and unambiguous symptomatic protein profiles. As focus shifts from glycomic discovery and characterization to that of glycan expression levels and minute perturbations in site occupancy, the need for robust and efficient glycan and glycopeptide quantitative strategies steadily grows.…”