Abstract:Background: Statins may trigger apoptosis in tumour cells in vitro and, particularly, melanoma cells are susceptible to statin induced apoptosis. Lipophilic statins (e.g. Atorvastatin, Simvastatin) induce strong caspase 3 activation after 48h of treatment, whereas hydrophilic statins (e.g. Pravastatin, Rosuvastatin) do not trigger caspase activation. Recently, we demonstrated the presence of an autocrine amplification loop which increases apoptosis by a caspase 8 dependent pathway after treatment with lipophil… Show more
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