Abstract 2935: Defining variation within a next gen humanized immune system mouse model of human lung cancer in the context of a checkpoint inhibitor efficacy study
Abstract:Humanized immune system mice are critical immuno-oncology tools, and next gen models using human cytokine-expressing mice, such as the NOG-EXL expressing hGM-CSF and hIL-3, drive differentiation of specific cell types. The huNOG-EXL (engrafted with human CD34+ hematopoietic stem cells) is widely used as it develops both myeloid and lymphoid lineages. Our goal was to determine the degree of variance between stem cell donors, tumor types, and immune cell reconstitution (tissue, phenotype and/or kinetics) within … Show more
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