Abstract:Antitumor antibodies like Rituximab and Trastuzumab activate the patient’s immune system to engage malignant cells. Despite the advances achieved by their introduction in cancer treatment, an urgent medical need remains to improve and optimize the efficacy of antibody therapy. This may be achievable using the cytokine IL-15 which induces proliferation and activation of both, NK cells and CD8 T cells, and enhances their cytolytic capacity. So far, short half-life, poor accumulation at the tumor site and severe … Show more
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