Abstract:Objective: Cancer progression is facilitated by a complex network of interactions between cancer cells and host-derived components, such as stromal cells and extracellular matrix in the tumor microenvironment. We sought to identify the factors that mediate these dynamic cancer-host interplays. Specifically, we asked how the host responds to signals from the cancer cells. To this end, we investigated the role of ATF3, an adaptive-response gene in the cellular stress response network. Overwhelming evidence indic… Show more
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