Abstract 263: Epidemiology of primary lung cancer and its trend northeast of Iran during 1985-2012

Abstract

Introduction: In this study we investigated epidemiology and trends of primary lung cancers in northeast of Iran during 1985-2012. Methods: In this cross-sectional study records of primary lung cancers from 1985 to 2012 in Mashhad, northeast of Iran, were investigated. Data were obtained from the referral oncologic hospital and private radiation oncology clinic. To study trends, the duration of study was categorized into three periods: 1985-1995, 1995-2005 and 2005-2012. Statistically significant level was considered <0.05. Results: Of 939 cases with mean age of 60.57 (±12.31) years, 660(70.3%) were male. Male to female ratio was 2.36. Mean age was 61.47±12.01 years for males and 58.45±12.75 for females (p=0.001). Mean age at diagnosis and rate of smokers was unchanged in three intervals (table 1). Time period1985-19951995-20052005-20012P valueAge(years)60.67±11.7460.57±12.2460.49±12.940.98Gender:Male167(78.4)330(68.6)163(66.5)0.01female46(21.6)151(31.4)82(33.5Male to female ratio3.632.181.99Smoking history:Yes69(76.7)211(67.8)100(65)0.15no21(23.3)100(32.2)54(35)Smokers:Male59(85.5)159(75.4)74(74)0.16Female10(14.5)52(24.6)26(26)Male-to-female ratio of smokers5.93.062.84 Squamous cell carcinoma with relative frequency of 44.2% was the most frequent pathologic subtype in total population followed by adenocarcinoma (18.2%), Small Cell Lung cancer (16.8%), large Cell carcinoma (1.3%) and other subtypes (19.5%). Relative frequency of pathologic subtypes had significant changes in three intervals (p <0.001). Relative frequency of adenocarcinoma and large cell carcinoma were increasing while it was decreasing for SCC and SCLCs during three recent decades. There was statistically significant difference in mean age at diagnosis (p<0.001), rate of smokers (p<0.001) and male to female ratio (p=0.01) between four leading pathologic subtypes. Mean age at diagnosis (55.92±12.90 years), male to female ratio (1.69), and rate of smokers (46.8%) were lowest in adenocarcinomas. Conclusion: Similar to universal picture, adenocarcinoma showed increasing rates during recent three decades with higher prevalence among younger aged patients, women and nonsmokers. These trends are indicative of changes in exposures and smoking habits and reveal the need for regional studies in this context. Citation Format: Maryam Salehi, Pardis Shojaee, Soodabeh Shahidsales, Seyed Amir Aledavood, Mehdi Seilaniantoosi, Golboo Goshayeshi, Fahimeh Khoshroo. Epidemiology of primary lung cancer and its trend northeast of Iran during 1985-2012 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 263. doi:10.1158/1538-7445.AM2017-263