Abstract:Background: Many different types of cancer (renal, lung, colorectal, prostate, uterus, breast and pancreatic) have already been associated to polymorphisms of the Renin Angiotensin System (RAS) genes. Angiotensin II (Ang II) is a vasoconstrictor, a mitogen and a angiogenic factor, whereas the angiotensin-(1-7) [Ang-(1-7)] has vasodilator, antiproliferative and anti-angiogenic properties. Classically, Ang II and Ang-(1-7) exert their effects through the AGTR 1-2 and the MAS1 oncogene receptors respectively. The… Show more
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