“…TOM40 protein levels also were reduced in neurons isolated by laser capture microdissection from a mouse PD model compared with levels in neurons from unaffected controls[116]. By contrast, TOMM40 mRNA and protein levels were elevated in tumor cells [66] compared with expression levels in adjacent, non-disease tissue. Learning the biological consequences of altered TOM40 expression will contribute to a deeper understanding the role TOM40 plays in regulating mitochondrial function, and possible new insights to the pathogenesis of these diseases..…”