Abstract:VHL disease is a classic tumor suppressor gene syndrome characterized by development of specific types of tumors in selective organs with nervous system and kidney being most consistently affected. Detailed studies on human spinal cord and cerebellum have previously revealed earliest stages of CNS tumorigenesis and the morphologic sequence resulting in development of frank tumors.
To elucidate earliest stages of renal clear cell carcinoma, we performed a similar approach in kidney tissues of fou… Show more
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