Abstract 2390: Increased detection of circulating prostate epithelial tumor cells on microfluidic channels using enhanced staining and automated scanning
Abstract:INTRODUCTION Anti-cytokeratin antibodies are typically used to detect circulating tumor cells (CTC) of epithelial origin in the blood of cancer patients. Cytokeratin (CK) is a cytoplasmic structural protein. We have previously described the CEE Enhanced TM (CE) technology for in situ fluorescence labeling of the capture antibodies used to isolate CTCs in our microfluidic channel. The signal intensity of cells stained by CE therefore reflects the number of antibody-targeted surface antigens on each cell. In thi… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.