Abstract:Introduction: Ferlins are an evolutionarily conserved family of proteins that play a variety of roles associated with plasma membrane dynamics in eukaryotes, including membrane repair and endocytosis. Myoferlin (MYOF) is a mammalian ferlin protein with homology to ancestral Fer-1, a C. elegans protein that regulates Ca2+-dependent spermatic membrane fusion, a key mechanism underlying the amoeboid-like movements of C. elegans sperm. Consequently, mutations in fer-1 lead to immotile C. elegans sperm and infertil… Show more
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