Abstract:Thyroid cancer incidence is increasing at an alarming rate almost tripling every decade. Although the majority of thyroid tumors are treatable, about 2-3% of thyroid cancers, mainly anaplastic thyroid cancer (ATC) is refractory to mainstream therapies. Driver mutations like BRAFV600E, PI3KCAE545K prompted development of targeted therapies with kinase inhibitors for ATC, but several reports suggest development of resistance. Given the refractory nature of ATC, it is imperative to explore alternative targets usi… Show more
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