Abstract:Oncogenic activation of the Wnt/β-catenin signaling pathway is common in hepatocellular carcinoma (HCC). Aberrant hypermethylation of tumor suppressor genes in their promoter regions is frequently found in human cancers. Our previous works have demonstrated that SOX1 gene was hypermethylated in HCCs as well as cervical and ovarian cancers. A growing number of papers suggest that SOX family proteins, such as SOX9, SOX17, SOX4 and SOX2, serve as either tumor suppressors or oncoproteins through manipulating Wnt s… Show more
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