Abstract:Introduction: Chromatin accessibility and cell-free DNA fragmentation patterns can be used to identify epigenomic mechanisms (Sharma et al. 2010) and infer cell-types contributing to cfDNA in pathological states such as cancer (Snyder et al. 2016; Ulz et al. 2017). We describe results from a novel blood-based cell-free DNA (cfDNA) assay using epigenomic signatures that have high sensitivity for detecting early stages of breast cancer, a cancer type that is characterized by low tumor burden (Phallen et al. 2017… Show more
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