Abstract:Metformin, the widely used and studied diabetes drug, has been reported to have anti-cancer effects. However, in retrospective clinical studies, the survival benefit associated with metformin use in cancer patients is often modest. Consequently, the design and conduct of sufficiently powered prospective clinical trials aimed at exploring this drug’s anti-tumor potential are hampered by the absence of predictive biomarkers. Testing the notion that specific patient characteristics such as obesity may impact the … Show more
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