“…6). A similar effect was also observed when fisetin and curcumin enhanced the treatment efficacy of 5-FU and other chemotherapeutic drugs by suppressing the expression of p-EGFR, p-HER2, p-IGR-1R, p-PI3K, p-Akt and p-mTOR in genetically modified in vitro and in vivo colon cancer models [41,42]. It has been previously reported that chemotherapeutic drugs induced DNA damage and consequently apoptosis activating the MAPK pathway [43].…”