Abstract:An immunosuppressive tumor microenvironment is considered one of the main problems in the treatment of different malignancies with immunotherapies like adoptive T cell transfer. Metabolites like lactate - which is produced by tumor cells even in the presence of sufficient oxygen ("Warburg-effect") - contribute to this setting. Another metabolic alteration found in many malignancies is a high level of 5‘-deoxy-5‘methylthioadenosine (MTA), due to a reduction of the catabolizing enzyme methylthioadenosine phospho… Show more
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