Abstract:Background: Immune checkpoint inhibitors (ICIs) have been proven to be very effective and have fewer side effects than conventional anticancer drugs by responding specifically to tumors. However, tumors developed resistance through various tumor-friendly factors, gradually weakening the effects of ICI. These factors suppress the activation of cytotoxic T-lymphocytes (CTLs), thereby inhibiting the ICI efficacy on tumors. Therefore, it is very important to develop a combination therapy that induces the anticance… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.