Abstract:T cell activation and exhaustion are associated with highly coordinated changes in gene expression and chromatin accessibility. While the contribution of key, state-specific transcription factors to these processes has been extensively explored, the role for chromatin regulatory complexes remains less clear. The mammalian SWI/SNF (mSWI/SNF) complexes are a diverse family of ATP-dependent remodeling complexes that regulate DNA accessibility and hence facilitate timely and appropriate gene expression. Recent gen… Show more
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