Abstract:Preeclampsia (PE), diagnosed by hypertension and proteinuria at or after the 20
th
week of gestation, is mediated in part by excessive immune system activation and inflammation. Ligand binding of the double-stranded RNA (dsRNA) receptors RIG-1, MDA-5, and TLR3 leads to innate immune system activation and inflammation. However, whether activation of all three receptors contributes to the development of PE is unknown. In placentas of women with PE there was significantly increased express… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.