Abstract:Sinoatrial node (SAN) automaticity is due to the interplay of several membrane currents, including the current produced by Na-Ca exchanger (NCX) in response to Ca cycling. Several lines of evidence suggest that inositol-1,4,5-triphosphate receptors (IP
3
Rs) that mobilize [Ca]
i
are implicated in generation of automaticity in embryonic and adult cardiomyocytes. Increased IP
3
R expression observed in failing heart may predispose to arrhyth… Show more
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