Abstract:Introduction:
While CI, or the inability of heart rate (HR) to adequately respond to exercise, is a strong indicator of mortality in HFpEF, treatment options remain limited as its mechanisms remain underexplored. Ionic remodeling of the SAN, both of the membrane (MC) and calcium clocks (CC), is associated with HFpEF and CI.
Aim:
Using an
in silico
approach, we investigated whether SAN ionic remodeling can contribute to 3 differen… Show more
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