Abstract:INTRODUCTION: Melanoma-acquired resistance against T cell-based immunotherapy may be mediated by alterations of their responses to inflammatory cytokines. However, the cytokine signaling pathways in cancer cells remain poorly understood.
METHODS: 8 melanoma cell lines were exposed to interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) over a time course. Signaling molecules and their phosphorylated state were subsequently analyzed using mass cytometry. Briefly, cells were incubated wi… Show more
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