Abstract 1609: Oxidation products of green tea polyphenols induce inactivation of PKC isoenzymes and induce cell death via modulation of selenoprotein thioredoxin reductase and quinone reductase
Abstract:Autooxidation of green tea polyphenols generates H2O2 and quinones which have been implicated in cell death induced by these polyphenols. While autooxidation of epigallocatechin-3-gallate (EGCG), the major green tea polyphenol, has been shown in vitro where oxygen tension is high, the role of reactive oxygen species in the action of EGCG in vivo is currently gaining attention. When DU145 prostate cancer cells were treated in vitro with EGCG, PKC isoenzymes were inactivated. This inactivation was strongly corre… Show more
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