Abstract 151: Association Between Glycated Hemoglobin A1c And SYNTAX Score In Non-Diabetic Patients Undergoing Coronary Artery Bypass Grafting

Abstract

Objective: SYNTAX score is now increasingly used as an index to guide further revascularization measures in patients with coronary artery disease. This study is aimed at finding association of glycated hemoglobin (HbA1c) and coronary artery disease severity and lesion complexity as assessed by SYNTAX score in non-diabetic patients who ultimately underwent coronary artery bypass grafting (CABG). Methods: A total of 587 non-diabetic patients who underwent CABG after coronary angiography from January 2007 to March 2010 were included in the study. Each patient’s SYNTAX score was calculated based on the coronary angiography. They were divided into four groups based on quartiles of HbA1c. Multivariate logistic regression analysis was performed to evaluate association of HbA1c to SYNTAX score and areas of lesions in individual coronary arteries. Results: The mean age of our population was 65 years with 77.3% males. The 4 quartiles of HBA1c were: HbA1c>=5.6%, HbA1c 5.7%-5.8%, HbA1c 5.9%-6.1% & HbA1c>=6.2%. There was no statistically significant association between HbA1c quartiles and SYNTAX score (p=0.54 for 4th vs. 1st quartile of HbA1c). Similarly, there was no statistically significant association between HbA1c and total number of diseased vessels (p=0.72) or total number of grafts used during CABG (p=0.40). We also found no statistically significant association between HbA1c levels and lesions at different anatomical sites: left main coronary artery (p=0.47), proximal left anterior descending (LAD) artery (p=0.92), mid-LAD artery (p=0.89), left circumflex artery (p=0.52) and right coronary &/or posterior descending artery (p=0.44). Conclusion: In non-diabetic patients undergoing CABG, there is no statistically significant association between HbA1c and location of coronary artery disease, number of diseased vessels or SYNTAX score.