Abstract 1508: Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects

Rayes, Roni F.; Mouhanna, Jack; Nicolau, Ioana; Vourtzoumis, Phil; Wong, Carson; Eustache, Jules; Giannias, Betty; Siblini, Aya; Lee, Emma; Sangwan, Veena; Rousseau, Simon; Quail, Daniela F.; Walsh, Logan A.; Bertos, Nicholas; Cools-Lartigue, Jonathan; Ferri, Lorenzo; Spicer, Jonathan

doi:10.1158/1538-7445.sabcs18-1508

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition t o d e f e n d i ng ag a i n s t m i c r o bi a l i nv a s i o n t h r o u g h phagocytosis and degranulation, neutrophils can undergo apoptosis after activation, and then form neutrophil extracellular traps (NETs), fibrinoid structures comprising extracellular chromatin and granulocyte proteins, including myeloperoxidase and neutrophil elastase, which were discovered because of their pathogen-trapping function, which can promote tumor metastasis by capturing circulating tumor cells and causing their proliferation at a second site (83,90). In EC patients without surgical stress or any other stimuli, tumors alone can induce high levels of circulating NETs, which are predictive of positive lymph node status, distant metastasis, and advanced disease stage (91).…”

Section: Neutrophilsmentioning

confidence: 99%

Innate Immune Cells in the Esophageal Tumor Microenvironment

Cui

Mei

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Esophageal cancer (EC) is one of the most common mucosa-associated tumors, and is characterized by aggressiveness, poor prognosis, and unfavorable patient survival rates. As an organ directly exposed to the risk of foodborne infection, the esophageal mucosa harbors distinct populations of innate immune cells, which play vital roles in both maintenance of esophageal homeostasis and immune defense and surveillance during mucosal anti-infection and anti-tumor responses. In this review, we highlight recent progress in research into innate immune cells in the microenvironment of EC, including lymphatic lineages, such as natural killer and γδT cells, and myeloid lineages, including macrophages, dendritic cells, neutrophils, myeloid-derived suppressor cells, mast cells and eosinophils. Further, putative innate immune cellular and molecular mechanisms involved in tumor occurrence and progression are discussed, to highlight potential directions for the development of new biomarkers and effective intervention targets, which can hopefully be applied in long-term multilevel clinical EC treatment. Fully understanding the innate immunological mechanisms involved in esophageal mucosa carcinogenesis is of great significance for clinical immunotherapy and prognosis prediction for patients with EC.

show abstract

Section: Neutrophilsmentioning

confidence: 99%

Innate Immune Cells in the Esophageal Tumor Microenvironment

Cui

Mei

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…They acted as a docking site for cancer cells to adhere in liver sinusoids before breaching the parenchymal. NETs induction either by primary tumors (147) or infections (148) can further enhance the intravascular arrest and seeding of metastatic cancer cells. An abdominal imaging window was developed for long-term visualization of liver metastasis over 14 days (149).…”

Section: Liver Cancermentioning

confidence: 99%

Live Imaging of Innate and Adaptive Immune Responses in the Liver

Zeng

2020

Front. Immunol.

View full text Add to dashboard Cite

Immune response in the liver is determined by the spatial organization and cellular dynamics of hepatic immune cells. The liver vasculature accommodates abundant tissue-resident innate immune cells, such as Kupffer cells, natural killer cells, and natural killer T cells, to ensure efficient intravascular immunosurveillance. The fenestrated sinusoids also allow direct contact between circulating T cells and non-canonical antigen-presenting cells, such as hepatocytes, to instruct adaptive immune responses. Distinct cellular behaviors are exploited by liver immune cells to exert proper functions. Intravital imaging enables real-time visualization of individual immune cell in living animals, representing a powerful tool in dissecting the spatiotemporal features of intrahepatic immune cells during steady state and liver diseases. This review summarizes current advances in liver immunology prompted by in vivo imaging, with a particular focus on liver-resident innate immune cells and hepatic T cells.

show abstract