Abstract:Introduction: Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. The balance between cancer cell proliferation and apoptosis, which maintains intestinal epithelial cell homeostasis, is disturbed in CRC. Furthermore, deregulation of the apoptotic pathway contributes to therapeutic resistance. Therefore, determination of the mechanisms employed by CRC cells to evade apoptosis is important for development of new therapeutic strategies. Our group has recently reported that neuropeptide … Show more
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