Abstract 142

Abstract

PurPose: The majority of chronic wounds occurs in people over age 60 and is increasing at a rate of approximately 10% per year. However, there is still no effective treatment method for such wounds because the mechanism has not been fully elucidated. We have found both high ROS production and MMPs expression in the ischemic wound of young animal, which correlated with high levels of MAPKs. The present study aimed to test the hypothesis that the ROS/MAPK/MMPs signaling axis plays an important role in pathobiological process of chronic wound in elderly by using small interference RNA (siRNA) approach in a novel ischemic wound model.