Abstract:PurPose: Fibroblasts represent a heterogeneous population of cells with diverse functional and phenotypic features. Such diversity remains largely undefined due to phenotypic drift in vitro and a lack of unique surface markers for functional subclasses of fibroblasts. Here we track the contributions of two distinct fibroblast lineages, defined by embryonic expression of Engrailed-1 (En1) and Wnt1, to connective tissue formation in the context of dermal development, cutaneous wounding, radiation fibrosis, and c… Show more
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