Abstract:Defects in DNA Damage Response and Repair are linked to the majority of cancers, including Prostate Cancer (PCa). Common genotoxic stresses that cause damage to the DNA, or replication fork collapse are generated when PCa cells face Androgen Deprivation Therapy (ADT), and must be bypassed to allow continuous replication and division. Tousled like kinase (TLK1) splice variant TLK1B is implicated in DNA damage repair pathways and is translationally increased following various stresses, including the DDR. We foun… Show more
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