Abstract:Introduction:
Adult women with LQT2 are at higher risk for clinical events and sudden cardiac death (SCD) than men. We have created transgenic rabbits over-expressing pore mutants of the human KvLQT1 (LQT1) and HERG (LQT2) selectively in the heart. We report the gender differences in cardiac repolarization, incidence of polymorphic VT and SCD in these cohorts.
Methods:
Adult female and male LQT1, LQT2, and littermate controls (ages 5 to 33 mo were simil… Show more
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