Abstract 13481: South Asian-specific
MYBPC3 25bp
Intronic Deletion Carriers Demonstrate Hypercontractility and Impaired Diastolic Function Under Exercise Stress
Abstract:Introduction:
A 25bp intronic deletion in
MYBPC3
(
Δ25bp
), present in 6% of US South Asians, is a risk allele for late onset left ventricular (LV) dysfunction and hypertrophy.
Hypothesis:
Asymptomatic
Δ25bp
carriers have detectable subclinical pathology to development of LV hypercontractility and impaired relaxation.
Methods:
To evaluat… Show more
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