Abstract:Background:
The cardiac dyad and associated calcium (Ca
2+
) release units (CRUs) are integral for cardiac excitation-contraction (E-C) coupling. The cardiac dyad is a multicomponent complex composed of the transverse-tubules, junctional sarcoplasmic reticulum (jSR), and CRU-associated proteins. Proper E-C coupling requires Ca
2+
influx via long-lasting-L-type Ca
2+
channels (Cav1.2), which triggers Ca
2+
… Show more
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