Abstract:Introduction: The paradigm of precision oncology is the selection of optimal therapy for individual patients. However, disease complexity prevents most cases from having a clear correlation between genetics and response, and programs using driver mutations to stratify patients into treatment arms have shown lackluster results (Middleton et al 2020). In contrast, prior work by us and colleagues demonstrated that functional analysis of drug action on single cells in unmanipulated primary tumor tissues with autom… Show more
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