Abstract 120: Peripheral Nerve Stimulation to Enhance Upper Limb Motor Function in Stroke

Abstract

Introduction: Peripheral sensory stimulation (PSS) administered for 2 hours prior to intensive task-oriented motor training delivered for 4 hours, over 10 days, leads to clinically significant benefits in subjects with stroke and moderate to severe upper limb motor impairment, compared to sham PSS. Whether similar results can be obtained with less intensive training programs remains to be determined. Methods: Twenty subjects with stroke in the chronic phase (>6m) and moderate to severe upper limb motor impairments were randomized to treatment with either 1.5h active PSS or sham, followed by functional electrical stimulation (FES) and task-specific training (TST) in sessions administered three times per week over six weeks. FES lasted for 30 minutes and TST, for 45 minutes. The primary outcome was the difference in performance in the Wolf Motor Function Test. The data were analyzed with a generalized estimating equations model with factors “group” (active or sham) and “time” (baseline, three and six weeks after starting treatment). Results: There were significant effects of “time” (Wald Chi-square = 16.5, p<0.001) and interaction between “group” and “time” (Wald Chi-square = 10.4, p=0.005) for the Wolf Motor Function Test, Functional Ability Scale. Post-hoc Bonferroni-corrected analyses showed a statistically significant improvement in performance between baseline and three weeks after beginning of treatment in the active (p=0.001) but not in the sham group (p=0.912). The difference between performance at baseline and six weeks after beginning of treatment almost reached statistically significance in the active (p=0.058) but not in the sham (p>0.999) group. Conclusions: These results are relevant for the design of larger clinical trials involving durations of interventions that are more easily implemented in clinical practice than rehabilitation protocols lasting for 6 hours per day. The study is ongoing.