Abstract:Inhibition of cardiac fatty acid oxidation (FAO) is considered beneficial after ischemia reperfusion (I/R). Krüppel-like factors (KLF) have an important role in metabolism. In a model of cardiac energetic deficiency (LPS-treated mice),
in silico
promoter analysis and whole genome array analysis indicated cardiac KLF5 as important regulator of
Ppara
. Gene expression analysis in human ventricular myocytes (AC16) treated with Ad-Klf5 followed by ChIP analysis confi… Show more
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