Abstract:Introduction:
The versatility of the human genome is increased by the process of alternative mRNA splicing. Impaired splicing of the cardiac transcriptome is involved in the pathophysiology of heart failure. Especially, mutations in cardiac-specific splicing factors such as RBM20 cause severe forms of cardiomyopathy.
Aim:
We aimed to identify novel cardiomyopathy-associated splicing factors in the human heart using a score of myocardial tissue specifici… Show more
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