Abstract 109: Immunomodulation Of Acellular Dermal Matrix Through Strategic Cytokine Incorporation Enhances Biointegration

Kang, Hannah; Nash, Victoria A.; Risser, Gregory E.; Zuang, Meng; Salopek, Lisa S.; Fraser, Cassandra L.; Campbell, Chris A.; Spiller, Kara L.; Cottler, Patrick S.

doi:10.1097/01.gox.0000667492.82650.5e

Cited by 1 publication

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Section: Discussionmentioning

confidence: 99%

“…We have preliminarily shown that adsorption of interleukin-4, which modulates macrophage-driven angiogenesis, onto acellular dermal matrix samples led to a statistically significant 3-fold increase in vascularization into acellular dermal matrix in our murine dorsal skinfold model of implant-based breast reconstruction. 78 Acellular dermal matrices serve as supportive and modulatory scaffolds in surgical wounds and are capable of host biointegration. Research on acellular dermal matrix use in breast reconstruction has mostly focused on clinical outcomes rather than the physiologic impact acellular dermal matrices have at the cellular level.…”

Section: Ementioning

confidence: 99%

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Acellular Dermal Matrix Favorably Modulates the Healing Response after Surgery

Plessis

Cottler

Campbell

2022

Plastic &Amp; Reconstructive Surgery

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Summary: When first described for breast reconstruction, the presence of acellular dermal matrices was associated with increased seroma formation and infection. However, clinical safety data have gradually improved with surgeon experience to an acceptable outcomes profile of acellular dermal matrix–assisted reconstruction when compared to submuscular implant coverage. In fact, acellular dermal matrix use potentially decreases capsular contracture rates and facilitates expansion for staged prepectoral breast reconstruction. Because of new regulatory requirements, the collection of unbiased, well-powered premarket approval data summarizing long-term clinical outcomes will be essential over the coming years to understand the clinical performance of acellular dermal matrix use in breast reconstruction. Currently, the authors can highlight the physiologic benefits of acellular dermal matrix use in breast reconstruction by evaluating the components of surgical wound healing that are favorably augmented by the implanted collagen substrate. Acellular dermal matrix takes advantage of the wound healing cascade to incorporate into the patient’s tissues—a process that requires a coordinated inflammatory infiltrate and angiogenesis. The presence of acellular dermal matrix augments and modulates the wound healing process to its advantage by simultaneously increasing the invasion of appropriate cellular constituents to facilitate expeditious healing and accelerate angiogenesis. In this article, the authors summarize the wound healing literature to demonstrate the mechanisms acellular dermal matrices use to biointegrate and the literature in which cellular constituents and soluble growth factors are up-regulated in the presence of acellular dermal matrix. Lastly, the authors use their experimental observations of acellular dermal matrix incorporation to corroborate the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Ementioning

confidence: 99%