Abstract 108

Abstract

78 lipoproteoplex by incorporating varying CSP:siRNA ratios into a standardized CLN and treated 3T3 fibroblasts to assess gene expression changes. Cellular internalization of fluorescent siRNA (siGLO) packaged in lipoproteoplex was visualized with fluorescent microscopy. In vivo, we applied lipoproteoplex with siGLO or siRNA to the skin of C57BL/6 mice. We then measured biodistribution via IVIS imaging, dermal penetration using histological sections, and gene expression in treated skin and internal organs 0-5 days post-treatment.