Abstract:Introduction:
Adenosine triphosphate - sensitive potassium (K
ATP
) channels provide endogenous myocardial protection by coupling cell membrane potential to metabolism, as they are inhibited by ATP and open during times of metabolic stress. Pharmacologic opening of K
ATP
channels mimics ischemic preconditioning, and diazoxide (DZX) preserves myocardial function following prolonged global ischemia.
Hypothesis:
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